StarCHO Feed Plus Medium is a premium high-concentration cell culture feed designed for advanced fed-batch bioprocesses using Chinese Hamster Ovary (CHO) cells. This enhanced feed medium features an optimized nutrient profile that supports maximum recombinant protein yields while maintaining excellent cell viability throughout extended culture periods.
StarCHO Feed Plus is a chemically defined feed medium formulated for high-density fed-batch processes across multiple Chinese hamster ovary (CHO) cell subtypes. It is hydrolysate-free, animal-origin free (AOF), and does not contain L-glutamine. It contains 83 g/L D-glucose.
Recommended cell subtypes: CHOZN GS-/-, etc.
Recommended companion media: StarCHO™, StarCHO™ Plus, and CDFS12™ Feed Supplement
This product is intended for research use or further manufacturing, including large-scale biopharmaceutical production. It is not intended for direct human administration or use as a drug substance or drug product.
Key advantages:
1) Enhanced nutrient formulation with increased concentrations of critical amino acids and growth factors;
2) Designed to work with StarCHO Plus Base Medium for synergistic performance;
3) Supports ultra-high cell densities (>15^7 cells/mL) in fed-batch processes;
4) Improves protein productivity by 30-50% compared to standard feeds;
5) Maintains optimal cell metabolism and reduces by-product formation;
6) Delivers high yields across different CHO cell lines while maintaining high cell densities and viability for robust bioprocessing;
7) GMP-ready for seamless R&D-to-GMP transition;
8) Robust intra- and inter-lot consistency (RSD <5%);
9) Flexible packaging formats (dry powder media or liquid).
StarCHO Feed Plus, used in combination with StarCHO Plus Medium and CDFS12 Feed Supplement, outperformed a competitor in CHOZN GS-/-mAb expression, showing 90% titer increase on Day 14, with higher late-stage VCDs and viability.
StarCHO Feed Plus Medium is ideal for cutting-edge biopharmaceutical manufacturing processes requiring maximum efficiency.
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