StarCHO Plus Medium is an enhanced version of the popular StarCHO Medium, featuring an advanced nutrient formulation optimized for Chinese Hamster Ovary (CHO) cells. This premium medium delivers superior cell growth performance, extended viability, and enhanced recombinant protein production efficiency compared to standard CHO media.
StarCHO Plus is a chemically defined basal medium formulated for thawing, passaging, and supporting high-density fed-batch processes across multiple Chinese hamster ovary (CHO) cell subtypes. It is hydrolysate-free, animal-origin free (AOF), and does not contain L-glutamine. It contains 6 g/L D-glucose.
Recommended cell subtypes: CHOZN GS-/-.
Recommended companion media: StarCHO™ Feed Plus and CDFS12™ Feed Supplement.
This product is intended for research use or further manufacturing, including large-scale biopharmaceutical production. It is not intended for direct human administration or use as a drug substance or drug product.
Key enhancements:
1) Advanced nutrient blend supporting higher cell densities and longer culture duration;
2) Improved buffering capacity for better pH control during high-density culture;
3) Enhanced amino acid profile supporting optimal protein synthesis;
4) Reduced lactate production and improved cell metabolism;
5) Compatible with both fed-batch and perfusion culture systems;
6) Delivers high yields across different CHO cell lines while maintaining high cell densities and viability for robust bioprocessing;
7) GMP-ready for seamless R&D-to-GMP transition;
8) Robust intra- and inter-lot consistency (RSD <5%);
9) Flexible packaging formats (dry powder media or liquid).
StarCHO Plus Medium, when fed StarCHO Feed Plus and CDFS12 Feed Supplement, outperformed a competitor in CHOZN GS-/- mAb expression, showing 90% titer increase on day 14, with higher late-stage VCDs and viability.
StarCHO Plus Medium is particularly well-suited for high-demand biopharmaceutical production processes requiring maximum productivity and consistent performance.
