CDFS36 CHO Feed Supplement is a specialized cell culture supplement designed to enhance the performance of CHO cell fed-batch cultures. This concentrated supplement contains a unique blend of growth factors, amino acids, and other essential nutrients that work synergistically with standard CHO feed media to significantly improve recombinant protein production and cell viability.
CDFS36 is a chemically defined feed supplement formulated for high-density fed-batch processes across multiple Chinese hamster ovary (CHO) cell subtypes. It is hydrolysate-free, animal-origin free (AOF), and does not contain L-glutamine.
Recommended cell subtypes: CHO-K1, CHOK1SV GS-KO, CHO-S, CHO-DXB11, Horizon CHO, CHO DG44, CHO-K1Q, etc.
Recommended companion media: Compatible with OPM basal media and feed media.
This product is intended for research use or further manufacturing, including large-scale biopharmaceutical production. It is not intended for direct human administration or use as a drug substance or drug product.
Key benefits:
1) Concentrated formulation requiring minimal addition volume;
2) Contains specialized growth factors to enhance cell proliferation and viability;
3) Optimized for use in late-stage production phase feeding;
4) Improves protein glycosylation and quality attributes;
5) Compatible with all major CHO feed media and cell lines;
6) Delivers high yields across different CHO cell lines while maintaining high cell densities and viability for robust bioprocessing;
7) GMP-ready for seamless R&D-to-GMP transition;
8) Robust intra- and inter-lot consistency (RSD <5%);
9) Flexible packaging formats (dry powder media or liquid).
CDFS36 Feed Supplement, used in combination with AltairCHO Medium and DenebCHO Feed, outperformed a competitor in CHO-K1 mAb expression, showing 62% titer increase on Day 14, with higher late-stage VCD and comparable or better viability.
CDFS36 CHO Feed Supplement is ideal for biopharmaceutical manufacturers looking to further optimize their existing fed-batch processes and achieve higher protein yields without major process modifications.
