AltairCHO Medium is a premium serum-free, chemically defined cell culture medium specifically formulated for the growth and maintenance of Chinese Hamster Ovary (CHO) cells. This advanced medium supports high cell density cultivation and enhances recombinant protein expression, making it ideal for biopharmaceutical manufacturing applications.
AltairCHO is a chemically defined basal medium formulated for thawing, passaging, and supporting high-density fed-batch processes across multiple Chinese hamster ovary (CHO) cell subtypes. It is hydrolysate-free, animal-origin free (AOF), and does not contain L-glutamine. It contains 6 g/L D-glucose.
Recommended cell subtypes: CHO-K1, CHOK1SV GS-KO, CHO-S, CHO-DXB11, etc.
Recommended companion media: DenebCHO™ Feed, SagiCHO™ Feed, VectorCHO™ Feed, and CDFS36™ Feed Supplement.
This product is intended for research use or further manufacturing, including large-scale biopharmaceutical production. It is not intended for direct human administration or use as a drug substance or drug product.
Key features include:
1) Serum-free and animal-derived component-free formulation ensuring regulatory compliance;
2) Optimized nutrient composition for maximum cell viability and productivity;
3) Consistent performance batch-to-batch;
4) Compatible with various CHO cell lines including CHO-K1, CHO-S, and DG44;
5) Supports both adherent and suspension cell cultures. Suitable for research, process development, and large-scale bioproduction;
6) Delivers high yields across different CHO cell lines while maintaining high cell densities and viability for robust bioprocessing;
7) GMP-ready for seamless R&D-to-GMP transition;
8) Robust intra- and inter-lot consistency (RSD <5%);
9) Flexible packaging formats (dry powder media or liquid).
AltairCHO Medium, when fed DenebCHO Feed and CDFS36 Feed Supplement, outperformed two competitors in CHOK1SV GS-KO mAb expression, showing 62% titer increase on day 14, with higher late-stage VCD and comparable or better viability.
