CDFS12 CHO Feed Supplement is a targeted cell culture supplement developed for specialized CHO cell bioprocesses. This supplement is formulated to address specific nutrient limitations that can occur in certain production systems, enhancing recombinant protein production while maintaining optimal cell health.
CDFS12 is a chemically defined feed supplement formulated for high-density fed-batch processes across multiple Chinese hamster ovary (CHO) cell subtypes. It is hydrolysate-free, animal-origin free (AOF), and does not contain L-glutamine.
Recommended cell subtypes: CHOZN GS-/-.
Recommended companion media: StarCHO™, StarCHO™ Plus and StarCHO™ Feed Plus.
This product is intended for research use or further manufacturing, including large-scale biopharmaceutical production. It is not intended for direct human administration or use as a drug substance or drug product.
Key features:
1) Targeted nutrient formulation addressing specific metabolic needs;
2) Designed for use in specialized CHO cell lines and expression systems;
3) Enhances productivity in challenging culture conditions;
4) Supports maintenance of desired protein quality attributes;
5) Easy to integrate into existing fed-batch processes;
6) Delivers high yields across different CHO cell lines while maintaining high cell densities and viability for robust bioprocessing;
7) GMP-ready for seamless R&D-to-GMP transition;
8) Robust intra- and inter-lot consistency (RSD <5%);
9) Flexible packaging formats (dry powder media or liquid).
CDFS12 Feed Supplement, used in combination with StarCHO Plus Medium and StarCHO Feed Plus, outperformed a competitor in CHOZN GS-/- mAb expression, showing 90% titer increase on Day 14, with higher late-stage VCDs and viability.
CDFS12 CHO Feed Supplement is recommended for biopharmaceutical applications requiring specialized cell culture conditions, including production of difficult-to-express proteins and complex biologics.
